The ultrastructural pathology study of the cuture cells infected with enterovirus 71
10.3760/cma.j.issn.1003-9279.2014.05.013
- VernacularTitle:肠道病毒71型感染细胞的超微病理研究
- Author:
Ying SONG
1
;
Jingdong SONG
;
Wenbo XU
;
Min WANG
;
Jianguo QU
;
Tao HONG
Author Information
1. 北京市仁和医院
- Keywords:
Enterovirus;
Virus/ultrastructure;
pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):358-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ultrastructure changes of the cells infected with enterovirus 71 (EV71) and location of virus particles in the cells.Methods Ultrathin sections of RD-A infected with EV71 were prepared and observed under a transmission electron microscope.Results Ultrastructure changes in the cells infected with EV71 include the followings:formation and proliferation of cytoplasmic bilaminated and muhilaminated membranes vesicular structures,formation of inclusion body,nuclear pyknosis,denaturation of mitochondria,distention of endoplasmic reticulum and degradation of host cells.EV71 virus particles locate in cytoplasm and vesicles,on surface of cytoplasmic membrane,within inclusion bodies,in endoplasmic reticulum cistern-like structures and in myelin figures.Conclusion Infection of EV71 in vitro can induce significant ultrastructural changes of host cells and virus particles present in diverse ultrastructures of host cell.
