Comparison of tuberculosis antibody test, adenosine deaminase activity test and interferon-gamma release assays in diagnosis of tuberculous pleurisy
10.3760/cma.j.issn.1003-9279.2014.05.012
- VernacularTitle:IFN-γ释放试验、腺苷脱氨酶活性检测和结核抗体检测用于结核性胸腔积液鉴别诊断的差异研究
- Author:
Ronglin SHEN
1
;
Jintian XU
;
Zhaojun CHEN
;
Jiabing MAO
;
Liquan HONG
;
Yuejuan FENG
;
Qun LÜ
Author Information
1. 310015,杭州师范大学附属医院呼吸内科
- Keywords:
Tuberculsis,pleural;
Interferon-type Ⅱ;
Adenosine deaminase;
Tuberculosis
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):355-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of interferon-gamma release assays (IGRAs) adenosine deaminase activity test (ADA) and tuberculosis antibody test (TB-ab) in diagnosis of tuberculous pleurisy.Materials Sixty-three patients with pleurisy were tested for IGRAs,ADA and tuberculosis antibody.Samples of blood were tested.IGRAs,ADA and tuberculosis antibody were diagnosed according to manufacturer' s instructions.Results Either of the method could detect several patients with tuberculous pleurisy.Tuberculosis antibody showed lowest sensitivity and specificity.In our experiments,ADA test only detected 58.14％ of patients,although specificity can be high.We detected highest percentage of tuberculous pleurisy (79.07％) in blood IGRAs,with a specificity of 70％.Conclusion Blood IGRAs are more effective than blood ADA and tuberculosis antibody test,and it is recommend that IGRAs should be used in diagnosis of tuberculous pleurisy.
