Effect of Feixian Fang extract on angiogenesis of pulmonary interstitial fi-brosis rats
10.3969/j.issn.1006-2157.2017.01.008
- VernacularTitle:肺纤方提取物对肺间质纤维化大鼠血管新生的影响
- Author:
Chen WANG
1
;
Zijuan WANG
;
Xiaomei ZHANG
;
Yuyue LIU
;
Zhe LIU
;
Huihui QIN
;
Ting Yu ZHANG
;
Lizhen GUAN
Author Information
1. 北京市中医医院顺义医院 北京 101300
- Keywords:
Feixian Fang extract(FXF);
pulmonary interstitial fibrosis;
electron microscopy;
microvascu-lar density;
platelet endothelial cell adhesion molecules 31,34 (CD31,CD34);
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2017;40(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective Feixian Fang is a Chinese medicine compound,formulated by the principle of in-vigorating lung and kidney,reducing phlegm and resolving masses,and promoting blood circulation to re-move meridian obstruction.This paper aimed to investigate the effect of Feixian Fang extract (FXF)on degree of pulmonary fibrosis,change of microvessels and platelet endothelial cell adhesion molecules (CD 31,CD34)in rats with pulmonary interstitial fibrosis.Methods All rats were divided into sham opera-tion group,model group,prednisone group,losartan group,FXF high-,mid-and low-dose group.Ex-cept the sham operation group,the rats of other six groups were instilled bleomycin of 3 mg/kg through tracheal intubation.The next day,the rats were administered intragastrically corresponding medicines for consecutive 14 d or 28 d.The degree of pulmonary fibrosis,change of microvessels were observed under electron microscope and the expression of CD31 and CD34 were detected using immuhistochemistrical methods.Results High dose and middle dose FXF inhibited the pulmonary fibrosis and pulmonary alve-olar inflammation and decreased microvascular density (P <0.05).Conclusion The effect of FXF a-gainst pulmonary interstitial fibrosis can be via the way of decreasing microvascular density to induce less abnormal angiogenesis in pulmonary fibrosis.
