Human papillomavirus infection of women with or without cervical lesions in Jiaxing in Zhejiang province
10.3760/cma.j.issn.1003-9279.2014.05.007
- VernacularTitle:浙江省嘉兴地区健康和宫颈病变妇女人乳头瘤病毒感染情况分析
- Author:
Chunsong YU
1
;
Minmin JIANG
;
Xiaoxiang LIU
;
Yanhong SUN
;
Aihua SUN
;
Jinqin JIANG
;
Jia ZHANG
Author Information
1. 嘉善县第一人民医院
- Keywords:
Papillomavirns,human;
Cervix disease;
Cervicitis;
Cervical intraepithelial neoplasia;
Genotypes
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):339-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective To survey prevalence of human papillomavirus (HPV) and their distribution characteristics in women with and without cervical lesions in Jiaxing,Zhejiang province.Methods The flow-through hybridization technique (HybriMax) was used to detect HPV genotypes in 426 cases of women with cervical lesions and 3134 women with normal cytology.Samples were collected from 4 hospitals in Jinhua,Zhejiang province.HPV infection rate and 26 kinds of genotype detection rate were compared in women with and without cervical lesions.Results HPV prevalences in 426 women with cervical lesions (26.29％) was significantly higher than that of 3134 women without cervical lesions (11.35 ％,P ＜ 0.01).HPV multiple infection rate of in HPV-positive women with cervical lesions (25.89％) was significantly higher than that of HPV-positive women without cervical lesions (4.78％) (P ＜ 0.01).High-risk HPV (HR-HPV) positive rate in cervicitis and cervical intraepithelial neoplasia (CIN) patients were 76.83％and 83.10％,respectively.CIN patients (83.10％) HR-HPV positive rate was higher than that of cervicitis patients (76.83％),but there was no significant difference.The five most common prevalent high-risk HPVs were HPV-16,33,58 and 18,52 in cervicitis patients,and HPV16,52 and 33,58,68 in CIN patients.Conclusion HPV prevalences in women with cervical lesions were higher than those of normal cytology women (P ＜ 0.01).Multiple infection with HPV was associated with cervical lesions.HPV-16,HPV-58,HPV-33 and HPV-52 were the most common prevalent high-risk HPV in HPV-positive women with cervical lesions.
