Expression of IL-6 and IL-18 in serum of patients with hepatic encephalopathy and its significance
10.3760/cma.j.issn.1003-9279.2014.05.005
- VernacularTitle:肝性脑病患者血清中IL-6和IL-18的表达及意义
- Author:
Changlong ZHENG
1
;
Xiaoan YANG
;
Yong ZOU
;
Qihuan XU
Author Information
1. 中山大学附属第三医院急诊科
- Keywords:
Interleukin-6;
Interleukin-18;
Hepatic encephalopathy;
Inflammation
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):333-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of IL-6 and IL-18 in serum and its correlation with aspartate aminotransferase (AST),alanine aminotransferase (ALT),total bilirubin (TBil),albumin (ALB),creatinine (Cr) and plasma ammonia in patients with hepatic encephalopathy.Methods Forty patients with liver cirrhosis complicated with hepatic encephalopathy were aligned to group A,where 18 patients with grade Ⅲ to grade Ⅳ were divided into group A1 and 22 patients with grade Ⅰ to grade Ⅱ were divided into group A2.Twenty liver cirrhosis patients were aligned to group B and 20 healthy persons were aligned to group C.The concentration of IL-6 and IL-18 in serum was detected by enzyme-linked immunosorbent assay (ELISA).The correlation between IL-6 or IL-18 and AST,ALT,TBil,ALB,Cr or plasma ammonia was analyzed by Pearson' s correlation analysis.Results Serum IL-6 and IL-18 levels in both A1 and A2 groups were significantly higher than those of group B and C.The difference was statistically significant (P ＜0.05).Both IL-6 and IL-18 levels were positively correlated with the ammonia,but there were no significant correlation with AST,ALT,TBil,ALB and Cr (P ＞ 0.05).Conclusion Serum IL-6 and IL-18 levels significantly increased in patients with hepatic encephalopathy.IL-6 and IL-18 may have a synergistic effect with ammonia,which were jointly involved in the pathogenesis of hepatic encephalopathy.
