Relationship between viral genotypes and follicular helper T lymphocyte and interleukin-21 and its significancein patients with HBV-induced hepatic cirrhosis
10.3760/cma.j.issn.1003-9279.2014.05.003
- VernacularTitle:乙型肝炎肝硬化患者病毒基因型与滤泡辅助性T淋巴细胞及白细胞介素-21的关系和意义
- Author:
Xibing GU
1
;
Yinfang ZHU
;
Juanhua WANG
;
Zhong HUA
;
Zhonghua LU
;
Xiaojuan YANG
;
Yueqin XU
Author Information
1. 214005,无锡市第五人民医院肝病科
- Keywords:
Hepatitis B;
Liver cirrhosis;
Genotype;
T lymphocyte;
Interlukin-21;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore relationship between different HBV genotypes and peripheral blood follicular helper T lymphocyte (Tfh) and interleukin-21 (IL-21) and its significance in patients with HBV-induced hepatic cirrhosis.Methods HBV genotypes were tested in 59 cases of cirrhotic hepatitis B with positive human leukocyte antigen (HLA)-A2,differences of Tfh and IL-21 between patients infected with genotype B and genotype C were compared and its significance was investigated.Results In 59 cases of cirrhotic hepatitis B,36 cases (61.02％) were infected with genotype C,22 cases (37.29％) were infected with genotype B and 1 case (1.69％) was infected with genotype B and C.Peripheral blood Tfh level of genotype C was(2.89％ ± 1.44％),lower than that of genotype B (4.65％ ± 1.37％),t =3.01,P ＜0.01,IL-21 level of genotype C was (14.62 ± 2.12 ng/L),lower than that of genotype B (32.27 ± 11.25ng/L),t =4.12,P ＜0.01,HBV specific cytotoxic T lymphocyte(CTL)level of genotype C was (0.17％ ±0.02％),lower than that of genotype B(0.37％ ±0.03％),t =3.12,P ＜0.01,HBV DNA level of genotype C was (6.95 ± 0.75log10copies/ml),higher than that of genotype B (5.02 ± 0.36 log10 copies/ml),t =3.03,P ＜ 0.01.Conclusion Compared with cirrhotic hepatitis B patients infected with genotype B,peripheral blood Tfh level of patients infected with genotype C was lower,causing lower IL-21 level and lower HBV specific CTL level,which result in higher HBV DNA level.
