379 Cases of HCV infected with hepatitis c virus and anti HCV and liver function index correlation analysis
10.3760/cma.j.issn.1003-9279.2014.04.017
- VernacularTitle:379例HCV感染者丙型肝炎病毒载量与抗HCV及肝功能指标的相关性分析
- Author:
Maoshan HUANG
1
;
Qiuying WANG
;
Yucai FANG
;
Xiaolei GAO
Author Information
1. 浙江省桐庐县富春江中心卫生院
- Keywords:
Hepatitis C;
RNA;
Alanine transaminase;
Bilirubin;
Polymerase Chain reaclion
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(4):291-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective Hepatitis c patients with HCV RNA loads and anti HCV and liver function index of correlation.Methods Retrospective analysis in January 2011 to December 2013 in our hospital outpatient,hospital,medical examination in patients with hepatitis c antibody positive,male 150,female 229,age 32-87,application of real-time fluorescent quantitative PCR detection of HCV RNA viruses,automatic biochemical analyzer test liver function 8 indicators,according to the number of HCV RNA viral load points HCV RNA negative groups,HCV RNA in the low level group,high levels of HCV RNA.Results Three groups of age distribution proportion by the statistical test has no obvious difference (P ＞ 0.05),but low in the proportion of women is slightly higher than that of males,Three groups of liver function and biochemical indicators is not identical results (P ＜ 0.05 or P ＜ 0.01),of which the HCV RNA in the low level group and high level of serum ALT,AST,GGT and ALP,TBIL compared with negative groups have difference (P ＜ 0.05 or P ＜ 0.01) ; TP,propagated,DBIL comparison,though no significant statistical differences between the three groups,but the low level and high level group results in a downward trend,in the low level and high level group comparison ALT,AST,TBIL also have obvious difference (P ＜ 0.05),viral load,the higher the ALT,AST results,after treatment with interferon with loads of decline index of liver enzymes.Conclusion No matter the discretion of the viral load to last as long as HCV RNA positive,can cause the damage of liver cells and liver function abnormalities,clinical should be antiviral treatment as soon as possible.Real-time PCR fluorescence probe technique is advanced,mature technology,stable results,to early diagnosis of HCV infection,help clinical early antiviral treatment,prevent the spread of HCV and development.
