Influence of Fructus Chebulae water solution on quality of Mongolian medicine Aconiti Kusnezoffii Radix Praeparata
10.3969/j.issn.1006-2157.2016.11.012
- VernacularTitle:辅料因素对炮制蒙药诃子制草乌质量的影响
- Author:
Shuai LIU
1
;
Weifei LI
;
Yan LI
;
Jinkai XU
;
Xiaoyan LIU
;
Fei LI
;
Hong DU
Author Information
1. 北京中医药大学 中药学院 北京 100102
- Keywords:
Aconiti Kusnezoffii Radix prepared with Fructus Chebulae;
processing;
excipients;
alkaloids content;
pH;
tannin
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(11):949-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of different concentration of Fructus Chebulae (Hezi)water solution on the quality of Aconiti Kusnezoffii Radix Praeparata (Zhicaowu),so as to optimize the process-ing technology and to find out the principle of detoxification of Hezi in processing.Methods Taking Hezi water solution with different concentration as the excipients,pH and content of total tannins were deter-mined.Then content of six alkaloids,indicator of toxic effect,in Zhicaowu were measured by reversed-phase HPLC.Results With the increasing of the concentration of Hezi water solution,the content of to-tal tannins increased,pH decreased at first,then kept stable,and the total six alkaloids increased slowly followed by irregularity.When the content ratio of Caowu to Hezi was 2∶1,consistent with Standard of Inner Mongolia Mongolian Medicines,the total alkaloids content was least.Conclusion Concentration of Hezi water solution and storage time changed the content of alkaloids in Zhicaowu.The content ratio of Hezi to Caowu recorded in Standard ofInner Mongolia Mongolian Medicines (in 1986)was scientific and valid.
