Serum levels of GP73 in patients with autoimmune liver disease
10.3760/cma.j.issn.1003-9279.2014.04.009
- VernacularTitle:自身免疫性肝病患者血清GP73变化特征
- Author:
Qingling ZHAI
1
;
Ran LIU
;
Zhiqiang WANG
;
Yubo HUANG
;
Xiaohua HAO
;
Xin FENG
;
Hongshan WEI
Author Information
1. 首都医科大学附属北京友谊医院
- Keywords:
Hepatitis,autoimmune;
Hepatitis;
Golgi apparatus;
Serum respense factor
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(4):268-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the serum levels of GP73 for diagnosing autoimmune liver disease.Methods Three populations were included:80 patients with autoimmune liver disease; 80 patients with chronic hepatitis B,and 80 apparently healthy controls.Results The serum levels of GP73 in patients with autoimmune liver disease (112.3 ± 72.55 ng/ml) were significantly higher than those of patients with chronic hepatitis B (86.44 ± 60.69 ng/ml),and healthy controls (35.84 ± 11.8 ng/ml).However,there were no significant differences was observed in group of subjects with autoimmune hepatitis (107.4 ± 90.6 ng/ml),primary biliary cirrhosis ((89.0 ± 45.38 ng/ml),and primary sclerosing cholangitis (113.3 ± 50.87 ng/ml).Chosen the healthy control as "control group",the patients with chronic hepatitis B as "patients group ",the sensitivity and specificity of GP73 for diagnosing autoimmune liver disease were 75.0％ and 97.53％,respectively.The area of ROC analysis was 0.93(95％ CI;0.89-0.97).Conclusion The serum GP73 levels was significantly increased in patients with autoimmune liver disease,compared with those of healthy controls.For patients with higher levels of serum GP73,diagnosis of autoimmune liver disease should also be considered,especially for those patients with overlap-syndrome,except for chronic virus hepatitis and hepatocellular carcinoma.
