Ancient TCM doctors’views on treatment of vertigo since Han Dynasty:a data mining research
10.3969/j.issn.1006-2157.2016.11.007
- VernacularTitle:汉代以来著名医家治疗眩晕方剂用药规律的数据挖掘研究
- Author:
Xudong LIU
1
,
2
;
Qingyong HE
;
Haifang WU
;
Xiaoxue ZHONG
Author Information
1. 中国中医科学院广安门医院 北京 100053
2. 北京中医药大学
- Keywords:
vertigo;
association rules;
data mining;
academic thought;
new drug research
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(11):920-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study 15 famous ancient TCMdocotors’prescribing herbal medicines for treat-ment of vertigo from Han Dynasty and the following periods,so as to provide basis for clinical treatment on vertigo as well as for researching and developing new medicines for treating vertigo.Methods A total of 128 traditional Chinese medicine prescriptions were collected and input into TCMInheritance Auxiliary Platform Version 2.5.Using the method of improved mutual information entropy clustering,association rules,complex systems entropy clustering and unsupervised entropy hierarchical clustering,the pattern types,pairs of drugs (two Chinese medicines used together),triangle drugs (three Chinese medicines used together),association rules of drugs,evolution and extraction of combination of the core drugs,and prescriptions newfound were analyzed.Results The leading pattern of vertigo was hyperactivity of liver yang (frequency:30;rate:23.4%.Same below).The most commonly used herbal medicine was Fuling (49,38.3%),and the most common pair of drugs was Zhigancao-Baizhu (29,22.7%),the most com-mon triangle drugs was Zhigancao-Baizhu-Fuling (17,13.3%).The drugs combination with high corre-lation was Baizhu-Danggui→Zhigancao,with support of 10% and confidence of 0.937 5.Altogether 22 sets of triangle drugs were extracted,in which the core drugs were Renshen,Baizhu,Zhigancao,Chen-pi,Fuling,Danggui.And 11 new prescriptions were available.Conclusion For research and develop-ment of new drugs on vertigo,we should focus on the pattern of hyperactivity of liver yang;prior compati-bility rules are Baizhu,Danggui with Zhigancao and Chenpi,Baizhu with Renshen and Zhigancao,Ren-shen with Baizhu;when formulate a new prescrption,Fuling,Fushen,Zhigancao,Chenpi,Sangye,Ju-hua,Baizhu and Renshen deserve the priority.
