Relationship between genotypes HBV C and B with specific cytotoxic T lymphocyte surface PD-1 expression in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2014.04.006
- VernacularTitle:慢性乙型肝炎患者HBV C、B基因型与特异性细胞毒性T淋巴细胞表面PD-1表达的关系
- Author:
Yulin ZHOU
1
;
Xuecai WANG
;
Yongfei TAN
;
Yanping ZHAO
;
Weiliang DING
;
Yinfang ZHU
Author Information
1. 214200,宜兴市人民医院感染
- Keywords:
Hepatitis B,chronic;
Genotype;
T lymphocytes cytotoxic;
Receptors,virus;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(4):258-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore relationship between genotypes HBV C and B with HBV specific cytotoxic T lymphocyte (CTL) surface programmed death receptor-1 (PD-1) and its significance in patients with chronic hepatitis B (CHB).Methods A total of 71 CHB patients were studied,human leukocyte antigen(HLA)-A2 positive,HBV DNA ＞ 103 copies/ml,of which 34 cases(47.89％)had genotype C and 36 cases (50.70％) had genotype B.Peripheral blood HBV specific CTL surface PD-1 expression level,HBV specific CTL level,HBV DNA level,ALT and TBil levels of patients infected with genotype C and B were compared.Results HBV specific CTL surface PD-1 expression level of CHB patients infected with genotype C (37.30 ± 3.05％) was higher than that of patients infected with genotype B (26.19 ± 3.06％),t =15.47,P ＜ 0.001,HBV specific CTL level (0.25 ± 0.03％) was lower than that of patients infected with genotype B (0.45 ±0.13％),t =21.54,P ＜0.001,HBV DNA level (6.75 ±0.77 log10 copies/ml) was higher than that of patients infected with genotype B (4.96 ± 1.12 log10 copies/ml),t =7.93,P ＜ 0.001,ALT level (487.39 ± 87.36IU/L) was higher than that of patients infected with genotype B (235.25 ± 90.911U/L),t =12.32,P ＜ 0.001,TBil level (49.73 ± 6.45) was higher than that of patients infected with genotype B (28.48 ± 5.89％),t =9.01,P ＜ 0.001.Conclusion Peripheral blood HBV specific CTL surface PD-1 expression level of CHB patients infected with genotype C was higher than that of patients infected with genotype B,resulting in lower HBV specific CTL level and higher HBV DNA level of patients infected with genotype C than patients infected with genotype B,so damage to liver functions was more serious than patients infected with genotype B.
