Effect and mechanism of effective components of Mongolian medicine compound Shudage-4 against experimental stomach ulcer
10.3969/j.issn.1006-2157.2016.10.011
- VernacularTitle:蒙药复方述达格-4有效部位抗实验性胃溃疡的作用及其机制
- Author:
Yinfei DU
1
;
Haofei ZHOU
;
Shasha XIN
;
Yang YANG
;
Yu DONG
Author Information
1. 内蒙古医科大学金山校区药学院 内蒙古 010110
- Keywords:
Shudage-4;
ulcer index;
nitric oxide;
malonydialdehyde;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(10):839-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect and mechanism of Mongolian medicine compound Shudage-4 on gastric ulcer induced by glacial acetic acid.Methods Healthy SD rats were randomly divided into Shudage-4 high,middle and low dose (high-,mid-,and low-dose)group,positive drug groups(Anweiyang group and cimetidine group),model group and normal group.Except for the normal group,the rats in the other six groups were modeled by glacial acetic acid.After the model was estab-lished successfully,rats of each group were admistered i.g corresponding medicine for consecutive 14 days.Then the gastric tissue was resected 24 h after the last administration.Ulcer index and ulcer inhabitation rate were measured,the content of NO and MDA in gastric mucosa were detected using ELIAS kits,and pathological changes of gastric tissue was stained by HE were observed under light microscope.Results Compared with the model group,the content of NO in gastric mucosa increased significantly and MDA decreased significantly in all three Shudage-4 groups (P <0.01).The inflamma-tion decreased in all three Shudage-4 groups,in which mid-group and high-group showed more obvious effect with much less the number of inflammatory cells and improvement of the pathological condition. Conclusion Mongolian medicine compound Shudage-4 has the therapeutic effect on gastric mucosal in-jury induced by glacial acetic acid in rats.The mechanism may be related to its effect of antioxidation and vasodilation.
