SENP1 severs a vital function in human glioma cells
10.3760/cma.j.issn.1003-9279.2014.03.013
- VernacularTitle:SENP1在人神经胶质瘤细胞中的重要作用
- Author:
Qiusheng ZHANG
1
;
Meng ZHANG
;
Xianjian HUANG
;
Xiaojia LIU
;
Weiping LI
Author Information
1. 508035广东,深圳市第二人民医院神经外科
- Keywords:
Glioma;
Mastadenovirus;
Apoptosis
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(3):197-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of sentrin/SUMO-specific protease 1 (SENP1) plays in human glioma cells by knockdown SENP1 with adenovirus transfection.Methods To knockdown SENP1,sh-SENP1 adenovirus were transfected into glioma cells LN229.The relative cell viability and apoptosis in glioma cells were observed to define the effect of SENP1 down-regulation on cell proliferation and apoptosis.And the effect of SENP1 down-regulation on cell migration was detected by a transwell migration system.Results SENP1 knockdown inhibited cell proliferation and induced apoptosis in human glioma cells.Further,we found that SENP1 knockdown obviously suppressed tumor cell migration.Conclusions These results demonstrate that SENP1 plays a critical role in human glioma cells.
