Influence of fluvastatin on aortic vascular remodeling by cytomegalovirus infection
10.3760/cma.j.issn.1003-9279.2014.03.012
- VernacularTitle:氟伐他汀对巨细胞病毒感染所致的血管重塑的影响
- Author:
Li YI
1
;
Riguang ZHAO
;
Houzhen TUO
;
Jiawei WANG
Author Information
1. 首都医科大学附属北京友谊医院神经内科
- Keywords:
Cytomegalovirus;
Vascular remodeling;
Metalloendopeptidases;
Fluvastatin
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(3):194-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the fluvastatin on apoE-/-mice vascular remodeling caused by cytomegalovirus (CMV) infection.Methods apoE-/-mice were infected with murine cytomegalovirus (MCMV).The extent of aortic atherosclerotic lesions,matrix metalloproteinase-9 (MMP-9) expression,and fluvastatin effects on these perspectives were observed.Results MCMV infection can aggravate apoE-/-mice aortic atherosclerotic lesion area and vascular cross-sectional area,and the expression of MMP-9; while fluvastatin can improve these indicators.Conclusion Fluvastatin can improve vascular remodeling by MCMV infection of apoE-/-mice.
