Clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang on patients with stage IV diabetic nephropathy
10.3969/j.issn.1006-2157.2016.09.016
- VernacularTitle:益气养阴消癥通络中药治疗 IV 期糖尿病肾病的临床研究
- Author:
Qian GUO
1
;
Zhiqiang CHEN
;
Jing FANG
;
Lu BAI
;
Yuehua WANG
;
Dengzhou GUO
;
Yuansong WANG
;
Chao ZHOU
;
Jianghua ZHANG
Author Information
1. 河北医科大学 河北 050017
- Keywords:
Yiqi Yangyin Xiaozheng Tongluo Fang;
diabetic nephropathy;
clinical trial;
irbesartan
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(9):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang (YYXTF),a Chinese medicine compounds formulated by the principle of replenishing qi,nourishing yin,eliminating abdominal masses,and freeing the collateral vessels,on patients with stage IV diabetic nephropathy (DN).Methods A total of 160 patients with stage IV diabetic nephropathy according to inclusion criteria were randomly divided into traditional Chinese medicine group (TCM group,n =81 ) and control group (n =79).In addition to general treatment,patients in TCMgroup took orally YYHXF and those in control group took irbesartan for consecutive six months.The incidence of end point events, improvement of clinical symptoms and urine micro-albumin excretion rate (mAlb),24 hours urine total protein (U-pro /24 h),serum creatinine (Scr),blood urea nitrogen (BUN),fasting plasma glucose (FPG),glycosylated hemoglobin (HbAlc),total cholesterol (TC)and triglycerides (TG)were recor-ded before and after treatment.Results During the follow-up period,compared with control group whose two patients with Scr >133 μmol /L,TCMgroup without patients progressing to stage V showed no statistical significance (P >0.05).Efficacy rate of relieving symptoms of hypodynamia,mouth dryness, back pain,edema in TCMgroup were significantly higher than that of control group (P <0.01).Intra-group comparison showed that mAlb and U-pro /24 h decreased after treatment (P <0.01).After treat-ment,mAlb and U-pro /24 h of TCM group were significantly lower than that of control group (P <0.05),and the level of TG of TCMgroup also decreased(P <0.05).Conclusion Yiqi Yangyin Hua-yu Tongluo Fang showed definite therapeutic effect on stage IV diabetic nephropathy proteinuria.It could reduce TG levels and protected against dyslipidemia.In addition,it relieved the symptoms and improved the quality of patients’life.
