Correlation of TA repeat polymorphisms of estrogen receptor-αgene and TCM patterns of hypomenorrhea
10.3969/j.issn.1006-2157.2016.09.007
- VernacularTitle:ERα基因 TA 重复序列多态性与月经过少中医证候相关性研究
- Author:
Xiaohua LIN
1
,
2
;
Zhe JIN
;
Jing LIU
;
Zhanwang TAN
Author Information
1. 河北省中医院 河北 050011
2. 北京中医药大学东方医院
- Keywords:
hypomenorrhea;
estrogen receptor-α;
TA repeat sequence;
TCMpatterns
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(9):734-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the distribution of TA (thymine-adenine)repeat polymorphisms of estrogen receptor-α(ERα)gene in patients with unexplained hypomenorrhea as well as its correlation with TCMpatterns of hypomenorrhea.Methods The present case-control study was carried out by using the sequencing methods to find out the TA repeat polymorphisms distribution differences in patients and controls,and in TCMpatterns of patients.Results The frequency of TA19 allele in experimental group was 22.73%,significantly higher than 4.55% in control group (P =0.007).The rank of distribution of TA19 allele in patterns listed as kidney deficiency,blood stasis and blood deficiency,showed no significant difference (X2 =5.137,P =0.077 ).But the distribution of TA19 in pattern of kidney deficiency and blood deficiency showed significant difference (X2 =4.574,P =0.032,OR =0.283). Conclusion The correlation of TA repeat polymorphisms of estrogen receptor-αgene and TCM patterns of unexplained hypomenorrhea was proved.The TA19 allele was more susceptibility to hypomenorrhea, whose association with the different TCMpatterns showed no statistical significance.
