The value of rubella IgG avidity test in the diagnosis of recent rubella infection
10.3760/cma.j.issn.1003-9279.2014.02.023
- VernacularTitle:风疹病毒IgG抗体亲和力检测对近期感染诊断的应用价值
- Author:
Junmei YANG
1
;
Jinxiang LI
;
Zhenxin GUO
Author Information
1. 450000,郑州市儿童医院
- Keywords:
Rubivirus;
Immunoglobuling G
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(2):142-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of rubella IgG avidity test in the diagnosis of recent rubella infection.Methods We detected the rubella IgG avidity of three groups of serum samples:48 acute infection samples from BIOMEX seroconversion panels RP-001,RP-014 and RP-011,38 rubella IgM positive samples,978 past infection samples (IgG positive IgM negative).Results All the acute infection samples from BIOMEX seroconversion panels RP-001 (50 days after infection),RP-014 (42 days after infection),RP-011 (71 days after infection) show IgG low avidity.Of the 38 rubella IgM positive samples,24 samples show IgG low avidity,9 samples show IgG high avidity,6 samples show grey zone.Of the 978 past infection samples,963 samples show IgG high avidity,9 samples show IgG low avidity,6 samples show grey zone.Conclusions Rubella IgG avidity test can be used to rapidly distinguish between past and acute infection.Of the rubella IgM positive samples,about 25％ show IgG high avidity,indicate past infection,so it is important to detect IgG avidity for this population.
