Prevalence of human Coronavirus OC43 infection among adult patients with acute respiratory infections in Beijing
10.3760/cma.j.issn.1003-9279.2014.02.014
- VernacularTitle:人冠状病毒OC43在北京成人呼吸道感染患者中感染的初步分析
- Author:
Qin HU
1
;
Roujian LU
;
Kun PENG
;
Wen WANG
;
Yanjie ZHAO
;
Yongliang LOU
;
Wenjie TAN
Author Information
1. 325035,温州医科大学
- Keywords:
Coronavirus OC43,human;
Reverse transcription polymerase chain reaction;
Respiratory tract infections
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(2):117-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prevalence and clinical features of human Coronavirus OC43 (HCoV-OC43) in adult patients with acute respiratory infections (ARI) in Beijing.Methods Nasopharyngeal swab specimens were collected from 559 adult patients with ARI.HCoV-OC43 infection was detected using two sets of OneStep reverse transcription polymerase chain reaction (OneStep RT-PCR),which targeted the spike and nucleocapsid coding region.Results The prevalence of HCoV-OC43 was 12.52％ (95％ CI:9.78％-15.26％),and the epidemic peak was in autumn.The dominant clinical presentations of HCoV-OC43 were fever,sore throat,headache,cough,nasal stuffiness,nasal discharge,and so on; 8 patients showed gastrointestinal symptoms such as diarrhea and vomiting.Statistically,nasal stuffiness was the most representative clinical presentation.Coinfection of HCoV-OC43 with other respiratory viruses was shown to be 35.71％ (25/70,95％ CI:24.49％-46.93％).Conclusion With sensitive molecular detection techniques and nasopharyngeal swabs,high rate of HCoV-OC43 infection was achieved in adult patients with ARI in Beijing.
