Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma.
- Author:
Young Sin KO
1
;
Young Ha OH
;
Chan Kum PARK
;
Wook Youn KIM
;
Hye Seung HAN
;
So Dug LIM
;
Tae Sook HWANG
;
Wan Seop KIM
Author Information
1. Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. wskim@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Lymphoma, large B-cell, diffuse;
Programmed death-1 (PD-1);
Lymphoma;
Prognostic factor
- MeSH:
B-Lymphocytes;
Humans;
L-Lactate Dehydrogenase;
Lymphocytes, Tumor-Infiltrating;
Lymphoma;
Lymphoma, B-Cell;
Lymphoma, Large B-Cell, Diffuse;
T-Lymphocytes;
T-Lymphocytes, Helper-Inducer
- From:Korean Journal of Pathology
2011;45(6):573-581
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Programmed death-1 (PD-1) is physiologically expressed by germinal center-associated helper T-cells and has an inhibitory effect on T-cell activity. METHODS: We examined 63 cases of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal antibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400x). RESULTS: Patients were divided into 2 groups: one with a high number of PD-1-positive cells (>20/HPF, n=33) and one with a low number of PD-1-positive cells (< or =20/HPF, n=30). The former group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score. CONCLUSIONS: The high number of PD-1-positive cells might be associated with an unfavorable outcome in DLBCL patients.
