Experimental study on protective effect of Glycyrrhizic acid phospholipid complex self emulsifying preparation against acute and chronic liver injury
10.3760/cma.j.issn.1003-9279.2014.01.008
- VernacularTitle:甘草酸磷脂复合物自乳化制剂对急慢性肝损伤的保护作用
- Author:
Renping RU
1
;
Jianfeng BAO
;
Ya ZHAO
;
Songlong LI
;
Qi WANG
;
Xiaobing MEI
;
Shourong LIU
Author Information
1. 310023,杭州市西溪医院(杭州市第六人民医院)
- Keywords:
Glycyrrhizic acid;
Liver diseases;
Pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(2):99-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Glycyrrhizic acid phospholipid complex self emulsifying preparation against carbon tetrachloride induced acute and chronic liver injury in rats and C57 BL/6J mouse.Method A cute hepatic injury rat model and a chronic hepatic injury were established by intraperitoneal (ip) injection with carbon tetrachloride (CCl4),the level of ALT and AST in serum were determined.The pathologic changes of hepatic tissue were observed with light microscope.Results The liver function results showed that Glycyrrhizic acid phospholipid complex self emulsifying preparation can significantly lower ALT and AST after acute and chronic liver injury (P ＜ 0.01).Hepatic pathology study showed Glycyrrhizic acid phospholipid complex self emulsifying preparation could alleviate hepatic inflammation and effectively protect liver cells.Conclusion It was revealed that Glycyrrhizic acid phospholipid complex self emulsifying preparation could prevent carbon tetrachloride from inducing liver injury.
