Affects of steatosis on liver stiffness values measured by transient elastography (Fibroscan) in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2014.02.007
- VernacularTitle:慢性乙型肝炎合并脂肪变对Fibroscan检测肝脏硬度值的影响
- Author:
Zhiqiang ZOU
1
;
Junmeng WANG
;
Li WANG
;
Youde LIU
;
Yanmei GUO
Author Information
1. 264001,烟台市传染病医院
- Keywords:
Hepatitis B,chronic;
Liver cirrhosis;
Fatty liver
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of steatosis on liver stiffness (LS) detected by transient elastography (Fibroscan) in patients with chronic hepatitis B (CHB).Methods 303 cases of CHB who underwent liver pathology and Fibroscan from January 2010 to May 2013 were retrospectively analysed.Biochemical parameters were collected.LS values in patients of CHB with and without steatosis were compared.LS values in patients of the same stage of liver fibrosis combined with different degrees of steatosis were compared using ANOVA.Cut-off values were obtained by Receiver Operating Characteristic (ROC curve) analysis.Results 273 cases were included when excluding BMI ＞ 28 kg/m2 and ALT ＞200U/ml.Steatosis was present in 75 (31.6％) cases,steatosis was absent in 162 (68.4％) cases.In every stage of fibrosis,combining with steatosis has no significant impact on LS values.LS(kPa) were 5.3 ±1.4vs5.9±1.9,9.5±4.2 vs8.7 ±3.0,18.4 ±7.5 vs 15.0 ±6.6,21.4 ±7.5 vs27.6±5.9 kPa,respectively.(P ＞ 0.05).While in the degree of F2,LS values in patients combined with the steatosis (S2) were higher than those in patients without steatosis (S0) (P ＜ 0.05) and with mild steatosis (S1) (P ＜0.05).LS values(kPa) were 11.28 ±5.54,8.68 ±2.95,8.12 ±2.44,respectively.Conclusions LS values have no significant difference in patients of CHB with steatosis and without steatosis with different degree of liver fibrosis.In patients with fibrosis stage of F2,LS values in those combined with moderate steatosis (S2) were higher than those without steatosis and with mild steatosis.
