Serum interleukin-32 expression level of patients with chronic hepatitis B treated with different antiviral drugs
10.3760/cma.j.issn.1003-9279.2014.02.004
- VernacularTitle:不同抗病毒治疗方案对慢乙肝患者IL-32表达水平的影响
- Author:
Canhui XIAO
1
;
Ying LIANG
;
Feifei HUANG
;
Ka ZHANG
;
Qihuan XU
Author Information
1. 南方医科大学第五附属医院感染科
- Keywords:
Hepatitis B,chronic;
Interleukin-32;
Antiviral agents
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(2):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression and significance of serum interleukin-32 of patients with chronic hepatitis B (CHB) treated with different anti-viral drugs.Methods One hundred and eighty CHB patients were randomly divided into two groups.The first group included 92 CHB patients,who were orally treated with lamivudine (LAM) 100 mg+ ADV 10 mg,once daily.The second group included 88 CHB patients who were subcutaneously treated with interferon (IFN),180 μg,once a week.The treatment period was 48 weeks.Serum IL-32 expression of patients was tested by ELISA,and the difference in IL-32 expression between two groups was compared by using statistical methods.Then the correlations between IL-32 and alanine aminotranferase (ALT),aspartate aminotranferase (AST),total bilirubin (TBIL),HBV DNA were analyzed,respectively.Results Serum IL-32 expression of all patients gradually decreased after anti-viral treatment,but the difference in IL-32 expression between two groups was not statistically significant until weeks 48.Serum IL-32 expression was positively related with serum ALT,AST and HBV DNA load,respectively,and was not related with serum TBIL.Conclusion Serum IL-32 expression of CHB patients gradually decreased after anti-viral treatment.IL-32 might be involved in the pathogenesis of CHB.
