Inhibition of Potentilla parvifolia on alpha-glucosidase and aldose reduc-tase
10.3969/j.issn.1006-2157.2016.07.012
- VernacularTitle:小叶金露梅对醛糖还原酶和α-葡萄糖苷酶的抑制作用
- Author:
Yuxia SUN
1
;
Yang ZENG
;
Qianru ZHANG
;
Tao YU
;
Meihua LI
;
Deping ZHAO
Author Information
1. 青海师范大学生命与地理科学学院青藏高原环境与资源教育部重点实验室 青海810008
- Keywords:
Potentilla parvifolia;
α-glucosidase;
aldose reductase;
inhibitory activity;
glucose tolerance
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(7):586-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory effects on α-glucosidase ( AG ) and aldose reductase ( AR) extracted from Potentilla parvifolia in different solvents , and to find out natural inhibitors of AG and AR.Methods With a combined vitro and vivo experiment design , this study measured the in vitro inhibitory effects of AG and AR extraction from Potentilla Parvifolia in three solvents:ethyl acetate ( total flavonoids ) , petroleum ether and water through AG inhibitors and AR inhibitory activity screening mod-els .In vivo effects of total flavonoids from Potentilla Parvifolia on impaired glucose tolerance of mice were also measured .Results Extraction of Potentilla Parvifolia in total flavonoids demonstrated a stronger in-hibitory effect on AR and AG .Its inhibitory effect on AG was higher than that of acarbose .Meanwhile , both high and low dose of total flavonoids improved glucose tolerance in mice .Conclusion Total fla-vonoids in Potentilla parvifolia exhibits inhibitory effects on AG and AR .
