Clinical observation of Bushen Qianggu Decoction on multiple myeloma
10.3969/j.issn.1006-2157.2016.06.017
- VernacularTitle:补肾强骨方治疗多发性骨髓瘤临床观察
- Author:
Zhili HUANG
1
;
Tianqi YU
;
Yayong CHEN
;
Shanshan GUO
Author Information
1. 广州市中医医院 广东510130
- Keywords:
Bushen Qianggu Decoction;
multiple myeloma;
macrophage migration inhibitory factor
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(6):520-523,528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Bushen Qianggu Decoction(BQD)onmacrophagemigra-tion inhibitory factor(MIF)of patients with multiple myeloma(MM)and its clinical efficacy,so as to pro-videthegroundforclinicalpromotion.Methods 30patientswhoaccordedwiththeinclusivecriteria were divided into two groups randomly.BQD combined with VAD chemotherapy regimen were used in treatment group;thalidomide combined with VAD chemotherapy regimen were used in control group.The indexes of pre-and post-treatment were observed,including serum MIF,hemoglobin,serum M protein, marrow plasmacyte rate,serum calcium,serum β2 microglobulin (β2-MG),lactic acid dehydrogenase (LDH),and C-reaction protein (CRP).And the clinical efficacy and adverse reaction were studied. Results There were statistical differences between treatment group and control group in serum MIF,he-moglobin,serum Mprotein,marrow plasmacyte rate,CRP (P<0.01)and β2-MG (P<0.05).There was no difference in serum calcium and LDH (P>0.05).The total effective rate in treatment group was 86.66% compared to 80% in control group,no significant differences after Ridit analysis (P>0.05). The incidence of constipation,sleepiness,edema,peripheral neuropathy of control group were signifi-cantlyhigherthanthatoftreatmentgroup(P<0.05).Conclusion Theclinical efficacy of BQDon MM was close to thalidomide with obviously less adverse reactions.BQD decreased serum MIF,M pro-tein,marrow plasmacyte rate,serum β2-MG,and CRP,increased hemoglobin,and adverse reactions were decreased significantly.This study showed that BQD has certain advantages on MM by the way of inhibiting the high expression of serum MIF and angiogenesis.
