The effect of N-acetylcysteine nano-carbon on anti-oxidative capacity in non-alcoholic steatohepatitis rats
10.3760/cma.j.issn.1003-9279.2014.01.002
- VernacularTitle:乙酰半胱氨酸纳米活性炭缓释微囊对大鼠非酒精性脂肪性肝炎抗氧化作用的影响
- Author:
Ling JIA
1
;
Jie WANG
;
Junping SHI
;
Fugen WANG
;
Hongying FANG
;
Mengfei ZHU
;
Guoqiang LOU
Author Information
1. 浙江中医药大学
- Keywords:
Acetylcysteine;
Charcoal;
Fatty liver;
Antioxidants
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(1):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of N-acetylcysteine nano-carbon (ACNAC) on antioxidative capacity in non-alcoholic steatohepatitis rats.Methods Rats non-alcoholic steatohepatitis model was established by means of high-fat diet in 12 weeks.Then the rats were treated with different doses of ACNAC (800 mg/kg,400 mg/kg and 200 mg/kg) and YISHANFU at the dose of 0.692 mg/kg,NAC at the dose of 400 mg/kg in astrolavaging perday.After 8 weeks,serological levels and liver tissue of SOD,MDA,GSH,GSH-PX in all groups were measured.Pathological changes of liver tissues under light microscope were observed.Results Compared with the high-fat group rats,the groups of medium dose and low dose of ACNAC in the serological levels of ALT,AST were decreased significantly,even lower than the group of YISHANFU.TCHOL,TG,LDL-C and CR were no statistical significance but decresed in date, and also lower than the groups of YISHANFU and NAC.The level of liver tissue in SOD,GSH,GSH-PX,the group of ACNAC were higher than the high-fat group's,and the level of MDA was lower than that.Conclusion Dose-related N-acetylcysteine Nano-carbon could enhance antioxidant capacity of NASH rats.
