Analysis of clinical characteristics between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2013.06.025
- VernacularTitle:HBeAg阴性与阳性慢性乙型肝炎患者临床分析
- Author:
Hong-Li XI
1
;
Min-Ren LI
;
Yi BAO
;
Xiao-Yuan XU
Author Information
1. 100034,北京大学第一医院感染性疾病科
- Keywords:
Hepatitis B,chronic;
Hepotitis B e antigens;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(6):472-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the characteristics of age,alanine aminotransferase (ALT) and hepatitis B virus DNA (HBV DNA) quantitative between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B.Methods The clinical datas of 125 patients with chronic hepatitis B were analyzed retrospectively.According to the expression of HBeAg,divided the chronic hepatitis B patients into two groups:HBeAg-negative and-positive.The datas of age,ALT and HBV DNA were analyzed by statistical methods.Results Among 125 patients,24 cases were HBeAg-negative group accounting for 19.2％ ; 101 cases were HBeAg-positive group accounting for 80.8％.The difference between two groups in average age and HBV DNA was significant,the comparison between ALT of two groups has no statistical significance.In HBeAg-negative groups,HBV DNA quantitative is lower,as the viral load increase,the number of abnormal ALT show a downward trend; In HBeAg positive group,HBV DNA quantitative is higher,as the viral load increase,the ALT abnormal quantity generally show a upward trend.Conclusions The age of HBeAgnegative chronic hepatitis B patients is larger than the HBeAg-positive patients,the level of ALT,HBV DNA quantitative in HBeAg-negative chronic hepatitis B patients lower than the HBeAg-positive patients,and as the viral load increase,the ALT abnormal number is on the decline,while the latter is opposite.
