Effects of curcumin on β-amyloid generating enzyme and degrading en-zymes in hippocampus in mice
10.3969/j.issn.1006-2157.2016.03.011
- VernacularTitle:姜黄素对小鼠海马 Aβ生成酶和降解酶的影响
- Author:
Yunfang DONG
1
;
Huili FENG
;
Yingkun HE
;
Hui FAN
;
Huizi DANG
;
Ying REN
;
Pengwen WANG
Author Information
1. 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室 北京 100700
- Keywords:
curcumin;
Alzheimer’s disease;
presenilin 2;
insulin degrading enzyme;
neprilysin;
mice
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(3):230-234
- CountryChina
- Language:Chinese
-
Abstract:
decreased significantly in the model group (P <0.01);compared with the model group,expressions of IDE and NEP increased significantly in all the intervention groups with IDE and NEP-positive cells in hippocampus CA1 region increasing(P <0.01 or P <0.05).Conclusion It is suggested that one of potential mechanisms of curcumin reducing Aβaccumulation may be via increasing Aβ-degrading enzyme IDE and NEP expression and reducing Aβ-generating enzyme PS2 expression.