Effects of curcumin on β-amyloid generating enzyme and degrading en-zymes in hippocampus in mice

VernacularTitle:姜黄素对小鼠海马 Aβ生成酶和降解酶的影响
Author: Yunfang DONG ¹ ; Huili FENG ; Yingkun HE ; Hui FAN ; Huizi DANG ; Ying REN ; Pengwen WANG
Author Information

1. 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室北京 100700
Keywords: curcumin; Alzheimer’s disease; presenilin 2; insulin degrading enzyme; neprilysin; mice
From: Journal of Beijing University of Traditional Chinese Medicine 2016;39(3):230-234
CountryChina
Language:Chinese
Abstract: decreased significantly in the model group (P <0.01);compared with the model group,expressions of IDE and NEP increased significantly in all the intervention groups with IDE and NEP-positive cells in hippocampus CA1 region increasing(P <0.01 or P <0.05).Conclusion It is suggested that one of potential mechanisms of curcumin reducing Aβaccumulation may be via increasing Aβ-degrading enzyme IDE and NEP expression and reducing Aβ-generating enzyme PS2 expression.