Analysis of risk factors, clinicopathologic characteristics and clinical interventions in patients with severe hand, foot and mouth disease
10.3760/cma.j.issn.1003-9279.2013.06.007
- VernacularTitle:手足口病重症化的危险因素、病理改变及临床干预
- Author:
Jing-Di ZHOU
1
;
Su-Wen JIANG
;
Ai-Rong HU
;
Yue-Can ZHANG
;
Yao-Ren HU
;
Nan-Hong ZHENG
Author Information
1. 315010,宁波市第二医院
- Keywords:
Hand,foot and mouth disease;
Risk factors;
Pathology;
Clinical medicine
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(6):420-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors and clinicopathologic characteristics of severe hand,foot and mouth disease (HFMD),and to provide a scientific basis for clinical interventions.Methods The clinical data of 2606 hospitalized children with HFMD in Ningbo No.2 Hospital were analyzed retrospectively from January 2010 to December 2012.Clinical characteristics were compared between two groups (regular case group and severe case group),and risk factors of severe HFMD were analyzed by Logistic regression test.The clinicopathologic features were analyzed from an autopsy case.Results Among total 2606 cases,619 cases were severe HFMD (23.7％).Logistic regression test showed that EV71 infection,poor spirit,blood glucose ＞ 9 mmol/L,high fever (temperature ≥ 39.1 ℃) lasted more than three days,younger than 3 years and abnormal neural reflex were the independent risk factors of HFMD seriousness.The results of the autopsy showed that the central nervous system,lung and intestinal were most severely.Conclusion Attention should be paid to observe the condition changes in HFMD patients with EV71 infection,younger than 3 years,nervous system symptoms,blood glucose ＞ 9 mmol/L and high fever.Targeted clinical intervention is particularly important for improving cure rate,and the protection of intestinal function can't be ignored.
