Blood-enriching effects and mechanism of albiflorin and paeoniflorin on immunosuppressional model mice with blood deficiency pattern
10.3969/j.issn.1006-2157.2016.03.007
- VernacularTitle:芍药内酯苷、芍药苷对血虚免疫抑制小鼠的补血作用及机制
- Author:
Yingli ZHU
1
;
Linyuan WANG
;
Danping ZHAO
;
Chenglong WANG
;
Li WU
;
Jianjun ZHANG
Author Information
1. 北京中医药大学 北京 100029
- Keywords:
albiflorin;
paeoniflorin;
blood deficiency pattern;
cytokines;
mice
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;39(3):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the blood-enriching effects and mechanism of albiflorin and paeoniflorin on immunosuppressional model mice with blood deficiency pattern induced by cyclophospha-mide.Methods The mouse model with blood deficiency pattern induced by intraperitoneal injection of cyclophosphamide was treated with intragastrical administration of albiflorin and paeoniflorin at high dose of 30 mg/kg,low dose of 15 mg/kg.Then the peripheral hemogram,thymus gland index and spleen index,granulocyte-macrophage colony stimulating factor (GM-CSF),interleukin-3 (IL-3),interleukin-6 (IL-6),tumor necrosis factor α(TNF-α)and granulocyte colony-stimulating factor were detected. Results High dose albiflorin and high dose paeoniflorin could increase WBC count(P <0.01 )and thymus gland index (P <0.01,P <0.05),serum contents of GM-CSF and G-CSF (P <0.001,P <0.01),also serum content of IL-3 (P <0.01,P <0.05),and decrease the serum content of IL-6(P <0.05)and TNF-α(P <0.001,P <0.01 ).Conclusion The blood-enriching effects against blood-deficiency via regulating the immunological function,suggests that albiflorin and paeoniflorin be the main effective components extracted from White Peony Root (Radix Paeoniae Alba,Baishao)with the effects of nourishing blood and liver.
