Relationship between Th17/Th1cells in peripheral blood and the rapid virologic response in patientswith chronic hepatitis C treated with pegylated interferon combined with ribavirin
10.3760/cma.j.issn.1003-9279.2012.03.020
- VernacularTitle:慢性丙肝外周血Th17/Th1水平与干扰素联合利巴韦林标准治疗快速应答的关系
- Author:
Feng LIAO
1
;
Xiao-Hong ZHANG
;
Qing-Xian CAI
;
Zhi-Xin ZHAO
;
Chao-Shuang LIN
;
Zhi-Liang GAO
Author Information
1. 中山大学附属第三医院
- Keywords:
Th17/Th1cells;
Hepatitis C,chronic;
Interferon alfa-2a;
Ribavirin
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(3):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Th17/Th1cells in peripheral blood and its relationship with rapid virologic response (RVR) to the therapy with pegylated interferon (PEG-IFN)combined with rib(a)ivirin (RBV) in patients with chronic hepatitis C (CHC).Methods Thirty one CHC patients treated with PEG-IFN combined with RBV were enrolled,and the demographic and clinical data including age,gender,body mass index (BMI),results of biochemical parameters in serum and the peripheral blood samples at baseline were collected. Eleven healthy volunteers were enrolled as control group.The RVR in 4th week were observed by prospective experimental research method. The ratio of CD3 +,CD8 -,IL-17 +,Th17 and CD3 +,CD8-,IFN-γ+,Th1in peripheral blood mononuclear cells (PBMCs) were detected at baseline by flow cytometry.Results Compared to the healthy control group,the level of Th1cells was decreased and the level of Th17 cells was increased in patients with CHC.In non-RVR group of CHC,compared to the healthy control group,the level of Th1cells was decreased significantly,and the level of Th17 cells was increased significantly ( P ＜ 0.05 ). Conclusions There was Th1/Th17 subgroups imbalance in no-RVR CHC patients treated with PEG-IFN combined with RBV,the level of Th1cells was reduced,and the level of Th17 cells was increased.The high level of TH17 cells and low level of Th1cells at baseline may not be conducive to the RVR.
