Clinical analysis of thyroid dysfunction induced by PegIFNα-2a therapy in chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2012.03.018
- VernacularTitle:聚乙二醇干扰素α-2a治疗慢性乙型肝炎引起甲状腺功能异常临床分析
- Author:
Ai-Min ZHANG
1
;
Keng CHEN
;
Xing-Hua TAN
;
Hui-Min FAN
Author Information
1. 广州市第八人民医院
- Keywords:
Hepatitis B,chronic;
Interferon alfa-2a;
Thyroid diseases
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(3):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects and treatment of thyroid dysfunction induced by PegIFNα-2a therapy in patients with chronic hepatitis B.Methods 95 patients with chronic hepatitis B received PegIFNα-2a from 2007-2011were selected. Analyzed the clinical manifestations,laboratory results,treatment and clinical outcome of the patients who had thyroid dysfunction induced by PegIFNα-2a therapy.Results During the treatment of PegIFNα-2a,10 patients ( 10/95,10.53％ ) had thyroid dysfunction,in which 4 were of hyperthyroidism and 6 were of hypothyroidism.After appropriate treatment,all the patients who had thyroid dysfunction had satisfactory outcome.Conclusions PegIFNα-2a therapy may induce thyroid dysfunction.Monitor thyroid function regular and have active treatment ensure the interferon therapy to continue.With the end of the interferon therapy,thyroid function can be back to normal.
