A retrospective analysis on therapeutic effects of oseltamivir treatment in patients with mild novel influenza A ( H1N1) virus infection
10.3760/cma.j.issn.1003-9279.2012.03.016
- VernacularTitle:奥司他韦对新型甲型H1N1流感轻症病例治疗效果的回顾性分析
- Author:
Guo-Liang ZHANG
1
;
Xiu-Hui LI
;
Zhang XIA
;
Ying-Xia LIU
;
Xing-Hua TAN
;
Yi-Mei TIAN
;
Liang-Chun LIANG
;
Guang NIE
;
Bo-Ping ZHOU
Author Information
1. 深圳市第三人民医院
- Keywords:
Influenza A virus;
Oseltamivir;
Retrospective studies
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(3):211-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effects of oseltamivir treatment in patients with mild novel influenza A ( H1N1) virus infection through a retrospective analysis.Methods Clinical data of 308 patients with influenza A (H1N1) was collected from 3 infectious diseases hospitals during May-August 2009,after exclusion of non-eligible cases,289 patients were divided into control group and oseltamivir treatment group,the duration of fever and viral load were compared between the 2 groups.Results Influenza A (H1N1) mostly affected 10 to 29-year-old persons,fever was the most common symptom which was low or moderate-level( ＜ 39 ℃ ),other symptoms involved sore throat,cough,headache,and rhinorrhea,a few patients had vomiting (1.3％)and diarrhea( 3.9％ ).Finally,there was no significant difference in duration of virus shedding from illness onset or beginning of therapy among the 2 groups(P =0.32,0.93 ).Conclusion The adolescents were main target of influenza A (H1N1) virus,most patients appeared to experience mild disease with better prognosis.For mild patients,oseltamivir could not shorten duration of fever and virus shedding effectively,and the virus could be cleared rapidly by immune system.Oseltamivir treatment had no clinical significance for mild influenza patients.
