Research on plasma metabolites of chronic heart failure patients with blood stasis pattern
10.3969/j.issn.1006-2157.2016.02.003
- VernacularTitle:慢性心力衰竭血瘀证患者血浆代谢物研究?
- Author:
Juan WANG
1
;
Huihui ZHAO
;
Jianxin CHEN
;
Dong DENG
;
Shuzhen GUO
;
Zhongfeng LI
;
Liangtao LUO
;
Wei WANG
Author Information
1. 北京中医药大学 北京100029
- Keywords:
nuclear magnetic resonance;
metabonomics;
chronic heart fallure;
orthogonal projections to latent structures-discriminant analysis
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;(2):101-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of metabolites in chronic heart failure ( CHF ) patients of blood stasis pattern by applying nuclear magnetic resonance ( NMR) . Methods Demographic data were collected from CHF patients of blood stasis pattern using cross-section survey. Their blood samples were also obtained and then magnetic resonance spectrum with pattern recognition techniques were used for in-tegral calculation and normalization based on chemical shift. All data were imputed into SIMCA-P soft-ware and the results were analyzed by using orthogonal projections to latent structures-discriminant analy-sis ( OPLS-DA) model. Results The OPLS-DA analysis of plasma samples could differentiate and pre-dict blood stasis pattern. Increased levels of lactate, alanine, and pyruvic acid with decreased levels of histidine, glycine, valineas, and other metabolites constitute the metabolomics profile of blood stasis pat-tern. Conclusion This study showed a profile of altered metabolites related to energy utilization and fat-ty acid metabolism in plasma samples of CHF patients with blood stasis pattern, which could offer a new approach to the diagnosis and treatment of CHF.
