Variations of hepatitis B virus S gene "a" determinant among children with failure of immunization in Huzhou city
10.3760/cma.j.issn.1003-9279.2012.03.005
- VernacularTitle:湖州地区乙肝疫苗免疫失败儿童乙肝病毒S基因“a"决定簇变异分析
- Author:
Fu-Chu QIAN
1
;
Wei-Hua ZOU
;
Ji-Qu QIN
;
Li-Cheng DAI
Author Information
1. 浙江省湖州市中心医院
- Keywords:
Hepatitis B virus;
Child hospitalzed;
Variation (genetics);
Genes
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(3):176-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variants of S gene of hepatitis B virus among the breakthrough infection children immunized with hepatitis B vaccine in Huzhou city.Methods HBV DNA S gene regions were amplified and sequenced in 29 children with HBsAg-positive/HBV DNA-positive after immunized with hepatitis B vaccine.Results The sequencing results showed that 26 cases were B genotypes,3 were C genotypes.The amino acids mutations were presented in 9 children serum HBV DNA.The major amino acid mutations were in the "a" determinant of HBV DNA S gene.Conclusion Different S gene variants maybe cause HBV vaccination failure in some children in Huzhou city.No predominant variant was found.
