Protective effect of Tangshenqing Formula II on renal function of type 2 diabetic mice
10.3969/j.issn.1006-2157.2016.01.003
- VernacularTitle:糖肾清2号方对2型糖尿病模型小鼠肾功能的影响?
- Author:
Jisheng ZHANG
1
;
Xuezheng SHANG
;
Yu BAI
;
Yanan WANG
;
Weiguo MA
;
Hui LIU
;
Kang WANG
;
Yi CHEN
;
Yan LU
;
Zhiming SHEN
;
Fengxian MENG
Author Information
1. 北京中医药大学东方医院 北京100078
- Keywords:
diabetic nephropathy;
renal function;
Tangshenqing Formula II;
mice
- From:
Journal of Beijing University of Traditional Chinese Medicine
2016;(1):16-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Tangshenqing Formula II ( TSQF) on the renal function of mice with type 2 diabetes mellitus ( DM) . Methods KK-Ay mice, a spontaneous DM mod-el, were fed with fat-enriched diet for three weeks. Based on their serum glucose ( Glu) and body weight ( BW) , the mice were divided into model group, valsartan group, high, middle, and low dose of TSQF ( high-, mid-, low- dose ) group ( n =6 each ) and were treated for consecutive 12 weeks. And six C57BL/6J mice were included into control group. At the timepoint of Week 0, 4, 8, 12, Glu, urine al-bumin ( Alb) , urine creatine ( Cr) , Alb/Cr( ACR) and 24-h urine protein ( pr/24 h) were detected. At the end of Week 12, all the mice were sacrificed and their serum samples were collected. And the serum levels of TG, TC, Scr, BUN and β2-MG were measured. Results Compared with the control group,
the levels of pr/24 h, ACR, Scr, TG and TC in the model group significantly increased ( P<0. 05 or P<0. 01), While BUN,β2-MG and ratio of kidney weight to body weight showed no statistcal differences (P>0. 05). Compared to the model group, the levels of Scr, TG and ACR in valsartan group and three TSQF groups significantly decreased (P<0. 05 or P<0. 01), and those of TC, Glu, and pr/24 h de-creased at different degree. Conclusion TSQF could reduce the serum levels of Glu, Scr and TG of kk-Ay mice, and alleviate the kidney injuries to reduce the progression of diabetic nephropathy.
