Identification renal disfunction in patients with cirrhosis using serum cystatin C
10.3760/cma.j.issn.1003-9279.2010.04.020
- VernacularTitle:应用血清胱抑素C检测乙型肝炎后肝硬化肾功能损害
- Author:
Xiu-Li WANG
1
;
Hong-Mei CHEN
Author Information
1. 解放军150中心医院
- Keywords:
Liver cirrhosis;
Cystatins;
Diagnosis
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(4):298-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the practical value of serum cystatin C (Cys C) for the evaluation of renal function in patients with cirrhosis. Methods One hundred and eighty two serum sample (including 91 cases of cirrhosis and 91 health individuals) were measured with partied-enhanced immunonepe lometry, which was compared with serum Urea and creatinine (Cr). Results The concentration of serum Cys C, Urea and Cr were ( 1.20±0.42 ) mg/L, (6.18±2.88 ) mmol/L and (70.48± 22.72) μmol/L in patients with cirrhosis. The concentration of serum Cys C and Urea were higher than those in health individuals with statistics significance( t test, P＜ 0.05 ). The serum Cys C could effectively detect renal disfunction in patients with cirrhosis, yielding a positive rate of 61.54% (56/91), which is higher than that of serum Urea and Cr(χ2 test, P＜0.05 ). Conclusion The serum Cys C is a potential biomarker to evaluate renal disfunction in patients with cirrhosis.
