Distribution of TCM syndrome elements at active stage and at stationary stage and their correlation with serum homocysteine level:a study of 715 patients with hepatitis cirrhosis
10.3969/j.issn.1006-2157.2015.11.009
- VernacularTitle:活动期与静止期肝炎肝硬化患者常见病性类证候要素的分布比较及其与血清同型半胱氨酸水平的相关性探讨
- Author:
Shuaiying HOU
1
;
Tianfang WANG
;
Xiaolin XUE
;
Xiuyan WU
;
Lihong ZHAO
;
Yonggang LI
;
Xin LI
;
Ning LI
;
Hong REN
;
Lulu LIU
;
Xiaona ZHANG
;
Qingxiang LUO
;
Jiayuan ZHANG
Author Information
1. 北京中医药大学 北京 100029
- Keywords:
liver cirrhosis;
syndrome elements;
homocysteine;
active stage;
stationary stage
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(11):756-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of distribution of TCMsyndrome elements of disease nature between active stage and stationary stage of patients with hepatitis cirrhosis,and to study the corre-lation between the TCMsyndrome elements and serum level of homocysteine (Hcy).Methods By using Information Collection Form ofHepatitis Cirrhosis drafted by our research team,a national multicenter and cross-sectional epidemiological survey was conducted to collect the general condition,symptoms,and blood samples from which the serum Hcy levels were obtained.In accordance with Standard ofHepatitis Cirrhosis Syndrome Elements Differentiation,the TCM syndrome elements of nature of the patients were determined.Then the correlation of the TCMsyndrome elements and the serum levels of Hcy was investi-gated at active stage and stationary stage.Results Altogether 715 patients were included.The frequen-cy of all syndrome elements in patients of active stage were higher than those in patients of stationary phase,in which the element of blood stasis,yin deficiency,qi deficiency,yang deficiency and water re-tention showed statistical differences (P <0.05).The serum level of Hcy in patients of active stage was higher significantly than that of stationary stage (P <0.05).The Hcy level of patients with yin deficiency pattern was lower than that of patients without yin deficiency pattern,the same as element of damp heat, qi stagnation and yang deficiency;however,the situations of element of blood stasis,qi deficiency and water retention were quite the reverse.In the patients of stationary stage,the serum levels of Hcy showed significant difference between qi stagnation group and non qi stagnation group (P <0.05).In the pa-tients of active stage,the levels of Hcy showed difference between yin deficiency group and non yin defi-ciency group,as well as the element of qi deficiency (P <0.05).Conclusion The frequency of TCM syndrome elements and the serum Hcy level in patients of active stage higher than those of patients of sta-tionary stage,reflected the degree of hepatic inflammation and severity of disease.That the correlation between the Hcy level and the TCMsyndrome elements of nature could provide the evidence for pathologi-cal basis and standardization study of TCMsyndrome elements in patients with hepatitis cirrhosis.
