Clinical study on serum autoantibodies of patients with chronic hepatitis C
10.3760/cma.j.issn.1003-9279.2010.04.015
- VernacularTitle:慢性丙型肝炎病毒感染者血清自身抗体检测的临床研究
- Author:
Yun-Zhong WU
1
;
Yao LU
;
Ge SHEN
;
Xing-Hong LI
;
Guo-Hua QIU
;
Yan SANG
;
Yan-Li ZHANG
;
Lin WANG
;
Lu ZHANG
;
Min YANG
;
Feng LIU
;
Ming-Hui LI
;
Yao XIE
;
Jun CHENG
;
Dao-Zhen XU
Author Information
1. 首都医科大学北京地坛医院
- Keywords:
Hepatitis C;
Autoantibodies;
Autoimmunity
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(4):282-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to detect serum autoantibodies of patients with chronic hepatitis C, and to explore the significance of autoimmunity in HCV infection. Methods We detected the autoantibodies, including ANA, anti-AMA, anti-Ro-52, of chronic hepatitis C patients ( n = 226) and chronic hepatitis B patients (n = 137 )retrospectively, and explored the relationship between the variation of autoantibodies and the HCV-RNA levels, biochemistry markers, age, gender, responses after interferon treatment. Results 34. 5% ( 78/226 ) and 7.3% ( 10/137 ) were respectively autoantibodies positive in patients with chronic hepatitis C and in patients with chronic hepatitis B (χ2 = 34. 396, P ＜ 0.05 ), and 30. 5% (69/226) of cases were ANA positive, otherwise,anti-ANA and anti-Ro-52 also weie detected. The isolating rate of autoantibodies was 40.7% in 150 patients with positive HCV-RNA ,comparatively, that rate was only 22. 4% in 76 negative HCV-RNA cases. The difference between the two groups was statistically significant(χ2 = 7.473, P＜0.05); The levels of ALT, AST, TBIL of negative autoantibodies cases and positive cases were (65.1±24.4 ) U/L, (47.4 ± 22.7 ) U/L, ( 17. 2 ± 8. 2 ) μ mol/L and ( 132.2 ± 49.3 )U/L, ( 100.7 ± 35.2 ) U/L, ( 35.5 ± 14.7 ) μ mol/L, respectively. The difference between the two groups is statistically significant ( t value was 16.012,14. 843 and 9. 000 respectively, overall P ＜ 0. 05 ); The isolating rate of autoantibodies in patients with hepatitis C was related with age, and not related with gender; the response rate of interferon treatment was 73.9% in patients with positive autoantibodies, and was higher than 54. 2% in patients without autoantibodies,but the difference was not statistically significant(χ2 = 0. 975, P ＞0.05). Conclusions HCV infection can induce autoimmune reaction to produce sevaral autoantibodies,especially in cases with positive HCV-RNA. The isolating rate of autoantibodies is highly related with age, it can be used for the diagnosis and treatment of hepatitis C to detect autoantibodies.
