Relationship between hepatitis B virus genotypes and hepatitis B virus large envelope protein (LHBS)
10.3760/cma.j.issn.1003-9279.2010.04.008
- VernacularTitle:慢性乙肝患儿HBV基因型与乙肝病毒大蛋白关系探讨
- Author:
Huai-Kai WEN
1
;
Jian YU
;
Li-Dan ZHU
;
Hong-Qun TAO
;
Xiang-Yang LI
;
Yi-Ping CHEN
;
Mi CHEN
Author Information
1. 温州医学院附属第二医院
- Keywords:
Hepatitis B,Chronic;
Genotype;
Viral envelope proteins
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(4):260-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between hepatitis B virus genotypes and hepatitis B virus large envelope protein. Methods A total of 138 surveyed children with chronic active HBV infection were enrolled real-time fluorescence PCR method was employed to quantify serum HBV DNA levels and classify the HBV genotypes. Hepatitis B virus large envelope protein was detected by using enzyme linked immuno sorbent assay (ELISA). Results The absorbance of hepatitis B virus large envelope protein was positively correlated with hepatitis B virus DNA levels (r=0.85, P＜0.05); Serum ALT levers, the absorbance of hepatitis B virus large envelope protein and hepatitis B virus DNA levels (P＞0.05,P＞0.05,P＞0.05), were no significant difference between hepatitis B virus genotype B and hepatitis B virus genotype C. Conclusion There was a close correlation between the absorbance of hepatitis B virus large envelope protein and HBV DNA levels. Hepatitis B virus large envelope protein was a reliable serological marker that can reflect the replication of hepatitis B virus and there was no relationship between hepatitis B virus genotypes and Hepatitis B virus large envelope protein.
