Preliminary study on distribution and relationship with phenotype of hepatitis B virus genotype detected from Xinjiang uygur autonomous region in China

VernacularTitle:新疆居民HBV基因型的分布及其与临床表现关系的初步研究
Author: Lei LI ¹ ; Yong-Liang FEI ; Yao YI ; Si-Yong CHEN ; Sheng-Li BI
Author Information

1. 新疆维吾尔自治区人民医院
Keywords: Hepatitis B virus; Genotype; Ethnic groups; Clinical medicine
From: Chinese Journal of Experimental and Clinical Virology 2010;24(4):257-259
CountryChina
Language:Chinese
Abstract: Objective To determine the main genotype of hepatitis B virus (HBV) in Xinjiang.Methods 200 HBsAg positive serum specimens were detected from more than 2000 serum of Xinjiang inhabitants, and HBV S gene was detected by using nPCR amplifying, and compared with the standard S region HBV nucleotide sequences of genotypes A-H retrieved from GenBank, then analyzed by MEGA3 and SAS3 software. Result Gene in 127 (63.5%) serum specimens was detected from 200 samples. Among 127 serum specimens, 10 (7.8%) was genotype B, 58 (45.7%) was genotype C, and 59 (46.5%) was genotype D. Han People were 51 (87.9%) in genotype D and 27(45.7%) in genotype D, Uygur were 24 in genotype D. Conclusion Genotype B(40.7%), C and D have been found in Xinjiang. Genotype C was more prone to causing severe liver disease.