Analysis of infection of Ureaplasma urealyticum/HPV in patients with cervical intra-epithelial neoplasia or cervical cancer
10.3760/cma.j.issn.1003-9279.2010.04.002
- VernacularTitle:解脲脲原体/HPV共感染与宫颈癌变的相关性探讨
- Author:
Shan CHEN
1
;
Na DI
;
Li ZHOU
;
Jun-Pu QIN
;
Di-Kai ZHANG
Author Information
1. 广东中山大学附属第六医院
- Keywords:
Ureaplasma urealyticum;
Papilloma virus,human;
Cervical intraepithelial neoplasia;
Cervical neoplasms
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(4):242-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of infection of Ureaplasma urealyticum(UU),HPV loading dose and CIN or cervical cancer, also the relationship of infection of Ureaplasma urealyticum,HPV genotype and CIN or cervical cancer. Methods One hundred and twenty-four patients in The sixth and second Affiliated Hospital of Sun Yat-sen University with CIN or cervical cancer were selected to be case group from September 2005 to January 2009. Three hundred health examining women were selected randomly by stratified sampling from medical examination center of the hospital during synchronization as control group. We detected Ureaplasma urealyticum, DNA quantitative expression of cervical secretions from patients with CIN or cervical cancer by means of Fluorescent quantitative PCR(FQ-PCR) and also HPV DNA by both Hybrid capture Ⅱ and flow-through hybridization and gene chip. Results The positive rate of UU in case group was 68. 5% , in control group was 38.7%. Compared positive rate of UU between case group and control group, the difference had statistical significance. In 124 cases detected for both UU DNA and HPV DNA, 58.9% were positive for both UU DNA and HPV DNA. Conclusion There may be some relationship between UU positive of lower genital tract and cervical intra-epithelial neoplasia or cervical cancer, especially there may be some relationship between UU positive and high-grade lesion of cervix.There maybe interaction between UU and infection of HPV.
