Study of serum level of cortisol and peripheral T lymphocyte subsets state in the hepatitis B virus carriers
10.3760/cma.j.issn.1003-9279.2008.05.004
- VernacularTitle:慢性乙肝病毒携带者外周血皮质醇水平与T细胞亚群状态的研究
- Author:
Xiao-Peng FAN
1
;
Kai WANG
;
Yu-Chen FAN
Author Information
1. 山东大学齐鲁医院
- Keywords:
Hepatitis B;
chronic;
Carrier state;
Cortisone;
T lymphocyte subsets
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(5):331-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study of serum level of cortisol and peripheral T lymphocyte subsets state in the hepatitis B virus (HBV) carriers. Methods Sixty chronic HBV carriers and ten healthy controls were all enrolled in this present study. Serum expression of cortisel was determined by radioimmunoassay, and also flow cytometry was performed to evaluate peripheral blood T lymphocyte subset. Results Compared with those in normal controls, the serous levels of cortisel in chronic HBV carriers were significantly elevated, while there was no distinct difference in the proportion of CD4+ T lymphocytes(P＞0.05) with the decreased odds of CD4+/CD8 lymphocytes(P＜0.05)and obvious higher proportion of CD8+ T lymphocytes(P＜0.05). In comparison between HBeAg positive group and HBeAg negative group, the serous levels of cortisol of the former group were significantly higher(P＜0.05), and so proportion of CD8+ T was too(P＜0.05). However, there is no significant differences in the proportion of CD4+ T lymphocyte (P＞0.05). Conclusion The elevated serum cortisol and increased CD8+ T lymphocytes subsets in the chronic HBV carriers, suggested that there was disturbance of endocrineimmune response in the chronicity of HBV infection.
