Quality representation and correlation analysis of medicinal preparation of Kaixin San based on drug system
10.3969/j.issn.1006-2157.2015.08.008
- VernacularTitle:基于药物体系的开心散药物制备物质量表征关联分析研究
- Author:
Huan-Juan LI
1
;
Lu ZHANG
;
Jian-Ye QUAN
;
Shu-Juan YANG
;
Yuan YANG
;
Wei CHEN
;
Dao-Han SUN
;
Duo FENG
;
Yan-Yan JIANG
;
Ren-Bing SHI
Author Information
1. 北京中医药大学中药学院 国家中医药管理局中药经典名方有效物质发现重点实验室 北京 100102
- Keywords:
drug system;
medicinal-preparation of Kaixin San;
quality characteristics;
correlation analysis
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(8):539-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the key factors affecting the quality of Kaixin San Heart-opening powder and the best preparation forms of Kaixin San,laying the groundwork of anti-dementia drug devel-opment from Kaixin San.Methods The content of effective index components of medicinal-preparation of Kaixin San was detected by using HPLC.The quality of medicinal preparation from Kaixin San were characterized based on the content,relative quantity,relative ratio of content,yield rate and anti-dementia effect,and the characterized results were given correlation analysis.Results The method of the determi-nation of effective index components from Kaixin San is easy to handle,accurate and highly reproducible. The effect of anti-dementia of three medicinal preparations from Kaixin San was listed in the following de-scending order of enrichment,ethanol extract,and water extract.The content of effective index compo-nents is higher with unique proportion,lower extraction rate,lower dosage and higher antibacterial effect, which is the best form in medicinal-preparation application of Kaixin San.Conclusion The key to the improvment of efficacy is to explore the fittest content and relative ratio of medicinal components based on the basic composition of Kaixin San and yield rate.
