Preliminary investigation of the relationship between liver lesion and relevant factors in young children with rotavirus diarrhea

VernacularTitle:轮状病毒腹泻患儿肝脏损伤及其相关因素的初步调查
Author: LINing ¹ ; Yingmin YAO ; Qiaoqun OU
Author Information

1. Nanfang Hospital The First Military Medical University
From: Chinese Journal of Experimental and Clinical Virology 2001;15(1):51-54
CountryChina
Language:Chinese
Abstract: Objective To investigate the possibility of liver lesion and its relationship with the rela tive factors in young children with rotavirus(RV) diarrhea. Methods The values of ALT and AST in sera of young children with RV diarrhea were measured to be compared with those of common diarrhea and were analyzed with the multifactors about diarrhea. The genomes of RV from blood serum were tested with reverse-nest polymerase chain reaction. Results Of the 41 young children with RV diarrhea, 15 (36.6 % ) and 32 cases (75.6%) were abnormally higher in the level of ALT and AST respectively and both the ratio and degree of increase were significant in comparison with that in control group. There was no significant relation between the changes of the values of ALT and AST and the clinical manifestation of diarrhea. 4 out of 41 cases were found to be positive of viremia. Conclusion RV infection might spread from intestine to blood and to other organs resulting in viremia, and the liver may be one of the organs involved.