The mRNA expressions of ILL-22,IL-22R1,STAT3 and c-myc in skin lesions of patients with psoriasis vulgaris and their correlations
10.3969/j.issn.1006-2157.2015.08.005
- VernacularTitle:寻常型银屑病患者皮损中IL-22与IL-22R1、STAT3、c-myc的mRNA表达及关系研究
- Author:
Xi CHEN
1
;
Ling-Ling LI
;
Run-Tian ZHANG
;
Meng XIA
;
Bin DONG
;
Xing-Wu DUAN
Author Information
1. 北京中医药大学东直门医院 北京 100700
- Keywords:
psoriasis vulgaris;
Interleukin-22;
IL-22R1;
Stat3;
c-myc
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(8):529-531,555
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of IL-22,IL-22R1,Stat3 and c-myc mRNA expressions in abnormal proliferation of keratinocytes in psoriasis vulgaris.Methods Biopsies of skin lesions were conducted in 23 patients with psoriasis vulgaris and the skin samples of 11 normal control subjects.Lev-els of IL-22,IL-22R1,Stat3 and c-myc mRNA expressions were measured with reverse transcription-poly-merase chain reaction (RT-PCR).Results IL-22,IL-22R1,Stat3 and c-myc mRNA were positively expressed in the psoriatic skin lesions as well as the normal controls.But the levels in the psoriatic skin lesions were significantly higher than those in the normal controls (P <0.01).There were positive corre-lations between the expression of IL-22 mRNA and that of IL-22R1 /Stat3 mRNA (P <0.05 ).There were also positive correlations between the expression of Stat3 mRNA and that of c-myc mRNA (P <0.05).Conclusion The activation of Stat3 induced by IL-22 may lead to excessive proliferation of ke-ratinocytes in psoriasis vulgaris,which could provide a new perspective in the treatment.
