A Case of Familial Hemiplegic Migraine.
- Author:
Young SA-KONG
1
;
Bong Hwan LEE
;
Sang Nam BAE
;
Kyun Woo LEE
;
Sang Ook NAM
Author Information
1. Department of Pediatrics, Dae Dong Hospital.
- Publication Type:Case Report
- Keywords:
Familial hemiplegic migraine;
Mutations;
CACNA1A gene;
Chromosome
- MeSH:
Calcium Channels;
Chromosomes, Human, Pair 19;
Epilepsy;
Genetic Linkage;
Genetics;
Headache;
Hemiplegia;
Humans;
Inheritance Patterns;
Male;
Migraine Disorders;
Migraine with Aura*;
Migraine without Aura;
Mutation, Missense;
Neurons
- From:
Journal of the Korean Child Neurology Society
2003;11(2):367-371
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Familial hemiplegic migraine(FHM) is an autosomal dominant subtype of migraine with aura, characterized by the occurrence of hemiplegia during the aura. Two subforms of FHM families exist; pure FHM in 80% and FHM families with cerebellar symptoms in 20%. Half of the known FHM families show genetic linkage to chromosome 19p13, and in these families FHM is caused by missense mutations in a neuronal P/Q type calcium channel alpha-1 subunit gene(CACNA1A gene). Linkages to 1q31 and 1q21-23 have also been established. Other families are linked neither to chromosome 19 nor 1. Clinical variabilities are partially associated with the various types of CACNA1A gene mutations. FHM is distinguished from more frequent migraine types by a clear, dominant inheritance pattern and the relative absense of other headache types. Further investigation of FHM will help to clarify the genetics of more common migraine. We describe a male patient with FHM with a brief review of the literature.
