Effects of acupuncture with different stimuli intensity on uterine contraction and expression of endocrine-related molecular receptor genes in rats with dysmenorrhea of cold coagulation pattern
10.3969/j.issn.1006-2157.2015.06.013
- VernacularTitle:不同针刺刺激量对寒凝证类痛经大鼠子宫收缩强度及内分泌相关分子受体基因表达的影响?
- Author:
Wing-Sze HSU
1
;
Guo-Zhen ZHAO
;
Bo JI
;
Dan-Dan QI
;
Meng-Wei GUO
;
Xiao-Xuan REN
;
Ya-Fang ZHAO
;
Lu-Fen ZHANG
;
Xiao-Hong LI
;
Jiang ZHU
;
He ZHANG
;
Yan SONG
;
Ya-Li LIU
;
Ping ZHANG
Author Information
1. 北京中医药大学针灸推拿学院 北京100029
- Keywords:
dysmenorrhea;
uterine contraction;
different acupuncture stimuli;
deqi;
PGEP22;
PGE2α;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(6):426-429,432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of acupuncture with different stimulation intensity at Sanyinjiao (SP6) on uterine contraction and expression of endocrine-related molecular receptor gene in rats with dysmenorrhea of cold coagulation pattern and to explore whether there is association between“deqi ( qi arrival)” and stimulus intensity. Methods Diestrus female rats were randomly divided into 4 groups, in-cluding saline control group, model control group, deqi group ( with strong stimulus) and No deqi group ( with weak stimulus) . The levels of uterine contraction was recorded during 20 mins acupuncture treat-
ment. The expression of PGF2α mRNA was measured. Results Compared with the model control group, the uterine contraction wave number and uterine activity were significantly reduced in deqi group. The ex-pressions of PGF2αmRNA in both deqi and No deqi group were also reduced compared with model group. Conclusion Our finding indicates that using thick needles, deep insertion with hand-manipulation seems more effective and could achieve desired level of “deqi” in dysmenorrhea rats.
