Study of hepatitis C virus specific immuine responses in anti- HCV positive patients without hepatitis Cviremia
10.3760/cma.j.issn.1003-9279.2000.03.006
- VernacularTitle:抗一HCV阳性无病毒血症患者HCV特异性免疫反应研究
- Author:
Peng YA0
1
;
Xueling HU
;
Darong HU
Author Information
1. Beijing Army General Hospital
- Keywords:
Hepatitis C virus;
Immunity,cellular;
Viremia
- From:
Chinese Journal of Experimental and Clinical Virology
2000;14(3):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hepatitis C virus specific immune responses in anti - HCV positive patientswithout hepatitis C viremia. Methods 15 anti- HCV positive patients without hepatitis C viremia, 15 patientswith chronic HCV infection and 1 5 normal controls were selected for this study. The T cell responses, NK cell(natu-ral killer cells)activity Cytokine production and HCV specific antibodies were detected by MTT, LDH release andELISA. Results Our study showed that the T cell proliferative reaction of patients without hepatitis C viremia wassignificantly higher than that of patients with chronic HCV infection and normal controls and the T cell response forHCV core antigen were higher than NS3 and NS4, but there was no significant proliferative response to NS5 anti-gen. We also found that there were no differences in anti - HCV antibody production and NK cell activity betweenthe two groups and the level of IFN - γin patients without hepatitis C viremia was higher than that in patients withrersistent HCV infection. Conclusion There are a lot of advantageous changes of HCV specific humoral and cel-lular immume response in anti - HCV positive patients without hepatitis C viremia, these immune responses may playa role in clearance of HCV.
