ACTH and GC levels in patients with hepatitis cirrhosis at two stages and their correlation with TCM pattern elements
10.3969/j.issn.1006-2157.2015.05.013
- VernacularTitle:肝炎肝硬化患者促肾上腺皮质激素、糖皮质激素水平与中医证候要素的相关性探讨
- Author:
Feng-Run ZHAO
1
;
Li-Hong ZHAO
;
Tian-Fang WANG
;
Xiao-Lin XUE
;
Xiu-Yan WU
;
Yong-Gang LI
;
Ning LI
;
Si-Ying WANG
;
Hui-Yin YANG
;
Yu-Yong JIANG
;
YAN-Ling LIU
;
Sheng-Duo CHEN
;
Qiu-Yun ZHANG
;
Xiu-Hui LI
;
De-Wen MAO
;
Chang ZHANG
;
Wen LIU
Author Information
1. 北京中医药大学 北京100029
- Keywords:
liver cirrhosis;
compensated and decompensated stages;
pattern elements;
ACTH;
GC
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(5):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the levels of serum adrencortical hormone ( Adrenocorticotropic hormone, ACTH) , and glucocorticoid ( Glucocorticoid, GC ) between patients of hepatitis cirrhosis at compensated and decompensated stages, and to evaluate their correlation with common TCM pattern elements.Methods Using a unified “hepatitis cirrhosis clinical information collection list”, which is formulated by this team, we conducted a national multi-center cross-sectional epidemiological survey, to collect the general condition of patients, their symptoms and other information.We also collected their blood samples for standardized laboratory tests. Previously published consensus and guidelines on diagnosis and treatment of hepatic cirrhosis were reviewed.With reference to literature review of clinical investigation, and finally we came up with a“common pattern element identification standard for hepatitis cirrhosis” after two rounds of expert consensus verification process.According to this standard, we can analyze the pattern elements and compare the differences between serum ACTH and GC levels during compensated and decompensated stages, as well as those between the pattern elements of blood stasis, yin deficiency, damp heat, qi stagnation, Qi deficiency, Yang deficiency, and water retention.Results Compared with patients at compensated stage, ACTH and GC levels in patients at decompensated stage were elevated, with significant difference in GC levels (P<0.05).In patients at decompensated stage, levels of ACTH in patients with Yang deficiency group was significantly lower than those in groups without it (P<0.05);In patients with blood stasis at decompensated stage, the level of ACTH was significantly higher than those in groups without it ( P<0.05) , but GC was higher than that of the other groups ( P<0.05) in terms of pattern elements ( except water retention).Conclusion ACTH and GC levels in patients with hepatitis cirrhosis could reflect the severity of disease, and may suggest a certain correlation with TCM pattern elements of class of common diseases.
