Recent advances in organ-system-specific biological age
10.3760/cma.j.cn112338-20240626-00379
- VernacularTitle:器官系统特异性生物学年龄研究进展
- Author:
Shuyao SONG
1
;
Zhiyu WU
;
Dianjianyi SUN
;
Canqing YU
;
Jun LYU
;
Liming LI
;
Yuanjie PANG
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Biological age;
Aging;
Organ systems
- From:
Chinese Journal of Epidemiology
2024;45(12):1751-1760
- CountryChina
- Language:Chinese
-
Abstract:
Biological age (BA) is a marker to accurately assess aging, facilitating the prediction of age-related diseases and promoting healthy aging. In recent years, first- and second-generation organ-system-specific BA has been developed using chronological age (CA) or aging-related outcomes (mortality) as training phenotypes and data from questionnaires, physical examinations, clinical biochemistry, imaging, and multi-omics to investigate the specificity of organ systems aging. Here, we review the methodologies for constructing BA, current efforts to assess organ system-specific BA, and related genome-wide association studies (GWAS). Previous studies predominantly used the first-generation BA method, using CA as training phenotypes. Organ-system-specific BA can accurately predict the disease risk of corresponding organ systems. We propose the development of organ system-specific BA through second-generation BA models and conducting GWAS and Mendelian randomization studies to explore organ system-specific aging processes, which will provide a theoretical foundation for the clinical application of organ system-specific BA.
